The Effects of Plasma-Activated Saline and Medium on Colorectal Cancer in Rat Models and the Human Colon Adenocarcinoma Cell Line COLO 205

Colorectal cancer affects a large number of people. There is an urgent need to develop novel treatments for this disease. In recent years, research on medical applications atmospheric low temperature plasma (ALTP) has been actively conducted, and treatment one the targets. study, we focused colorectal evaluated as new method. vivo in vitro experiments were conducted using plasma-treated saline (PTS) medium (PTM) prepared by submerged bubbling ALTP. rat model revealed that PTS administration colon slowed tumor progression based endoscopic histopathological observations. To investigate cause inhibition progression, impact ALTP cells. As result culturing cells with PTM, cell proliferation was inhibited. Also, death induced swelling. qPCR PTMs through signaling necrosis factor ? (TNF-?), inflammatory cytokine. Therefore, occurs inducing dissolution components liquid.